Ūth Rejuvenation Crème

Functional

• Acacia senegal gum

  Acacia senegal gum is the dried exudate—a complex, loose aggregate of sugars [arabinose, galactose, rhamnose] and hemicelluloses—of Acacia senegal. Also known as gum arabic, it is commonly included in cosmetics as a fragrance ingredient or as a suspending and emulsifying agent 1, 2. Acacia gum is generally considered to be a nontoxic material when used topically 2.

• Aloe barbadensis leaf juice extract (Manapol)

  Aloe barbadensis leaf juice extract (Manapol)^® is a polysaccharide found in aloe vera gel. For centuries, the plant aloe vera has been used by cultures for its beneficial effects on human health 1. Today aloe vera gel continues to be used in supplements, foods, beverages, and cosmetics. Aloe leaves consist of two major parts, the outer leaf epidermis and the inner leaf gel, which are very different in their chemical composition and properties. Aloe gel, obtained from the inner portion of the leaves, is rich in nutrients and contains an abundant supply of glycoproteins and mono-, oligo- and polysaccharides. Monosaccharide constituents include glucose, mannose, galacturonic acid, glucuronic acid, galactose, arabinose, fucose, glucosamine, fructose, rhamnose and xylose

  Aloe leaves consist of two major parts, the outer leaf epidermis and the inner leaf gel, which are very different in their chemical composition and properties. Aloe gel, obtained from the inner portion of the leaves, is rich in nutrients and contains an abundant supply of glycoproteins and mono-, oligo- and polysaccharides. Monosaccharide constituents include glucose, mannose, galacturonic acid, glucuronic acid, galactose, arabinose, fucose, glucosamine, fructose, rhamnose and xylose 2. Much of the health benefits observed by the use of aloe vera gel may be attributed to its high molecular weight (MW) polysaccharides. Before a process was developed to stabilize aloe vera gel or extracts, fresh preparations were regarded as being required for any therapeutic efficacy

  Much of the health benefits observed by the use of aloe vera gel may be attributed to its high molecular weight (MW) polysaccharides. Before a process was developed to stabilize aloe vera gel or extracts, fresh preparations were regarded as being required for any therapeutic efficacy 3. It is now clear that careful drying of aloe vera gel can retain the polysaccharide content important for producing many of its health benefits 4. An ingredient exclusive to Mannatech, Manapol is obtained from fresh, washed and filtered gel by a specialized extraction method that yields insoluble fibers and stabilized, high MW soluble fibers rich in long-chain mannose sugars—beta-(1-4)-acetylated polymannans (acemannan)

  An ingredient exclusive to Mannatech, Manapol is obtained from fresh, washed and filtered gel by a specialized extraction method that yields insoluble fibers and stabilized, high MW soluble fibers rich in long-chain mannose sugars—beta-(1-4)-acetylated polymannans (acemannan)5. Mannose is an important glyconutrient sugar that supports cell-to-cell communication6.

  Aloe vera gel has a long history of use as a topical agent to soothe and hydrate the skin and enhance healing. Many attribute the benefits of topical and oral aloe vera gel to its acemannan content. 7. The acetylation (i.e., attachment of CHO groups) of acemannan appears to be crucial for solubility and its ability to induce fibroblast proliferation and stimulate fibroblasts to produce the dermal extracellular matrix protein collagen 7,8. Acemannan has also been shown to stimulate the production of growth factors involved in healing 9. The mechanism by which acemannan exerts these effects was recently shown to be via the AKT/mTOR signaling pathway 10. The MW of over 20% of Manapol is >800,000. Preliminary evidence suggests that superior immunologic benefits may be provided by higher MW aloe gel extracts that have a higher mannose content5,11. Aloe vera gel is also used in cosmetics and personal care products as a skin conditioning agent, which acts both to lubricate the skin surface and to increase water content of the top layers of the skin by drawing moisture from the surrounding air 12. According to the Cosmetic Ingredients Review (an independent committee established by the Personal Care Products Council, an industry trade association that thoroughly reviews and assesses the safety of ingredients used in cosmetics), Aloe barbadensis leaf extract is safe to use in the amounts present in our products .

• Astaxanthin

  Astaxanthin is an antioxidant 1compound that can be used in skin care products as a colorant or a skin-conditioning agent 2.

• Copper lysinate/prolinate

  Copper lysinate/prolinate is the copper salt of a mixture of the amino acids proline and lysine. It is included in skincare products as a conditioning agent 1.

• Crocus chrysanthus bulb extract

  Crocus chrysanthus bulb extract is an extract derived from the bulb of the crocus flower. Collagen, the main extracellular structural protein in the skin dermis, diminishes with age1. Elastin fibers in the dermis, key to supporting the elasticity of the skin, also diminish with aging2. Both of these structural components of the skin are produced by the most common cell in connective tissue: fibroblasts. Keratinocytes, cells on the surface of the skin, communicate with fibroblasts deep in the dermis, stimulating their ability to synthesis collagen and elastin3. A human clinical study indicated that Crocus chrysanthus bulb extract improved skin firmness; another study showed that it increased the collagen and elastin fiber content of the skin. The mechanism of these effects was explored in test tube studies, which showed that human skin fibroblasts exhibited increased expression of genes associated with markers of collagen/elastin assembly following exposure to culture medium from human skin keratinocytes exposed to Crocus chrysanthus bulb extract.

• Cynara scolymus (artichoke) leaf extract

  Cynara scolymus (artichoke) leaf extract is used in cosmetics as a skin-conditioning agent 1. In small company-sponsored clinical studies, application of preparations containing C. scolymus leaf extract reduced skin melanin content and improved skin texture and elasticity. In test tube studies, the mechanisms of these effects were explored. Preparations containing C. scolymus leaf extract inhibited basic fibroblast growth factor (bfGF) by human epidermal keratinocytes, inhibited epidermal melanocyte proliferation and inhibited skin cell melanin production.

• Ergothioneine

  Ergothioneine is a compound that is included in cosmetics because of its antioxidant properties 1.

• Ethylhexylglycerin

  Ethylhexylglycerin (also named octoxyglycerin) is an organic compound used in cosmetics and personal care products as a skin conditioning agent 1.
• Glycerin

  Glycerin is a chemical compound used in skin care products and cosmetics as a humectant, that is, a skin conditioning agent that increases water content of the top layers of the skin by drawing moisture from the surrounding air. Glycerin also acts as a lubricant on the skin surface, which gives the skin a soft and smooth appearance 1. It is included in the U.S. Food and Drug Administration (FDA) Inactive Ingredients Guide as safe to use in the amounts present in our products 2.

• Glyceryl linoleate

  Glyceryl linoleate is an organic compound used in cosmetics and personal care products to aid in stabilizing oil-in-water mixtures and as a skin-conditioning agent that acts as a lubricant on the skin’s surface, giving the skin a soft and smooth appearance 1. According to the Cosmetic Ingredient Review (an independent committee established by the Personal Care Products Council, an industry trade association that thoroughly reviews and assesses the safety of ingredients used in cosmetics), glyceryl linoleate is safe to use at the amounts present in our products 2.

• Helianthus annuus (sunflower) seed oil

  Helianthus annuus (sunflower) seed oil is the oil expressed from the seeds of the common sunflower. Sunflower oil is used in cosmetics and personal care products as a skin conditioning agent that slows the loss of water from the skin by forming a barrier on the skin’s surface 1. Sunflower oil is generally regarded as relatively nontoxic and nonirritating when used in cosmetics and personal care products 2.

• Hydrolyzed Viola tricolor extract

  Hydrolyzed Viola tricolor extract is an oligosaccharide-rich extract of the pansy V. tricolor. Small company-sponsored human clinical studies investigating emulsions containing hydrolyzed V. tricolor extract reported significantly reduced wrinkles and improved skin hydration. In test tube studies of human skin cells, hydrolyzed Viola tricolor extracts significantly stimulated the synthesis of aquaporin-3 (AQP) (a water channel in the lipid layer of human skin cell membranes); increased secretion of hyaluronic acid; and increased the synthesis of CD44, a hyaluronic acid receptor.

• Lens Esculenta (Lentil) Fruit Extract

  Lens exculenta (lentil) fruit extract , an extract of the fruit of the lentil plant, is used in cosmetics as a skin conditioning agent 1.

• Methylglucoside phosphate

  Methylglucoside phosphate is a complex misture of esters of phosphoric acid with the methyl ether of glucose. Methylglucoside phosphate is included in skincare products as a conditioning agent 1.

• Neopentyl glycol dicaprate

  Neopentyl glycol dicaprate is the diester of neopentyl glycol and decanoic acid. It is used in skin formulations as a conditioning agent/emollient 1.

• Silica

  Silica, the inorganic oxide of silicon, serves multiple functions in a wide range of cosmetic products, including exfoliating, absorbent, anti-caking, bulking, opacifying, suspending and nonsurfactant.1.

• Simmondsia chinensis (Jojoba) Seed Oil

  Simmondsia chinensis (Jojoba) Seed Oil is the oil expressed from seeds of the desert shrug, Jojoba. In skincare products, is functions as a skin conditioning agent 1.

• Sodium hyaluronate

  Sodium hyaluronate, is a viscous solution consisting of a high molecular weight fraction of purified natural sodium hyaluronate in sodium chloride. Hyaluronic acid is a natural complex sugar of the glycosaminoglycan family. In cosmetics it functions as a skin conditioning agent 1.

• Squalene

  Squalene is an unsaturated branched chain isoprenoid hydrocarbon that can be obtained from numerous plants sources, including olives, vegetable oils, amaranth seed, rice bran and wheat germ. It is widely used in cosmetics as a skin conditioning agent/emollient 1.

• Sucrose palmitate

  Sucrose palmitate is an organic compound used in cosmetics and personal care products to aid in stabilizing oil-in-water mixtures and as a skin-conditioning agent that acts as a lubricant on the skin’s surface, giving the skin a soft and smooth appearance 1.

• Tocopheryl acetate

  Tocopheryl acetate is an organic compound used in cosmetics and personal care products as a skin-conditioning agent. It also has antioxidant activities 1.
• Vaccinium myrtillus leaf extract

  Vaccinium myrtillus (Bilberry) leaf extract is included in cosmetics as a skin conditioning agent 1.

• Vitis vinifera (grape) seed oil

  Vitis vinifera (grape) seed oil is used in cosmetics as a skin conditioning agent 1.

Formulation

• Acrylamide/sodium acryloyldimethyltaurate copolymer

  Acrylamide/sodium acryloyldimethyltaurate copolymer is included in cosmetic products for stability or to increase their viscosity 1.

• Butylene glycol

  Butylene glycol is an organic compound used in cosmetics and personal care products to assist in mixing of ingredients or to reduce the thickness of liquids 1. According to the Cosmetics Ingredient Review (an independent committee established by the Personal Care Products Council, an industry trade association, that thoroughly reviews and assesses the safety of ingredients used in cosmetics), butylene glycol is safe to use in the amounts present in our products 2.

• C13-14 isoparaffin

  C13-14 isoparaffin is a mixture of organic compounds that aids in the dissolving and mixing of ingredients in cosmetics and personal care products 1.

• Citric acid

  Citric acid occurs naturally in a number of plant species, including lemons and pineapples. It is also found naturally in the human body, mainly in the bones. In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. As an excipient, it is used primarily to adjust the pH (the acidity or alkalinity) of a product 1. It is also used in skin care products for fragrance 2. Citric acid is considered generally recognized as safe (GRAS) and is approved for use as a food additive by the U.S. Food and Drug Administration (FDA) 3. It is also included in the U.S. FDA Inactive Ingredients Guide as safe to use in the amounts present in our products 4.
• Hydroxyethyl Acrylate/Sodium Acryloydimethyltaurate Copolymer

  Hydroxyethyl Acrylate/Sodium Acryloydimethyltaurate Copolymer is a polymer commonly used in cosmetics as an emulsion stabilizer, suspending agent or viscosity increasing agent 1.

• Laureth-7

  Laureth-7 is an organic compound that aids in the mixing of ingredients in skin care products 1.

  Phenoxyethanol

  Phenoxyethanol is an organic compound used for fragrance and to preserve the quality of cosmetics and personal care products 1. According to the Cosmetic Ingredient Review (an independent committee established by the Personal Care Products Council, an industry trade association that thoroughly reviews and assesses the safety of ingredients used in cosmetics), phenoxyethanol is safe to use at the amounts present in our products 2.
• Polysorbate 60

  Polysorbate 60 is an organic compound used in skin care products as a fragrance and to aid in stabilizing oil-in-water mixtures 1. Polysorbate 60 is listed in the U.S. Food and Drug Association (FDA) Inactive Ingredients Guide as safe to use in the amounts present in our products 2.
• Potassium sorbate

  Potassium sorbate is an organic salt that is used for fragrance and to preserve the quality of skin care products 1. According to the Cosmetic Ingredient Review (an independent committee established by the Personal Care Products Council, an industry trade association that thoroughly reviews and assesses the safety of ingredients used in cosmetics), potassium sorbate is safe to use at the amounts present in our products 2.
• Sorbitan isostearate

  Sorbitan isostearate is the monoester of isostearic acid and hexitol anhydrides derived from sorbitol. It is used as an emulsifying agent in cosmetics and skincare products 1.

• Water (Aqua)

• Naturally gluten-free
• Gluten-free
• Allergy tested
• Dermatologist tested
• Paraben-free
• Hypoallergenic
• Never tested on animals
• Contains naturally sourced ingredients
• No artificial colors
• In a study of 53 adult men and women, Uth [did not induce allergic contact dermatitis/was non-irritating/was hypoallergenic]
  • Non-comedogenic
  • Will not cause your skin to break out
  • In a study of 15 adults, Uth [did not cause breakouts/was non-comedogenic]
• Safe for use around the eyes
• In a 4-week study of 31 adults, Uth was safe to use around the eye area

2 Applications/Day Uth Rejuvenation Creme

• In an 8-week human clinical study conducted by Thomas J. Stephens and Associates, Inc., twice daily use of Uth Rejuvenation Creme significantly improved skin. Subjects experienced improved firmness, elasticity, hydration, smoothness, radiance/brightness, tone, texture, lift, and jaw line contour. Subjects also experienced a reduced appearance of fine lines and wrinkles and photodamage.^ŧ
• Clinical subjects experienced the following improvements in their skin:^ŧ
  • Over 30% (30.3%) improvement in elasticity
  • Over 28% (28.9%) improvement in hydration
  • Over 21% (21.1%) improvement in firmness
  • 17% improvement in smoother-feeling skin
  • Over 11% (11.3%) improvement in the appearance of fine lines and wrinkles
  • Over 9% (9.8%) improvement in [radiance/brightness]
  • 9% improvement in [overall appearance/photodamage]
  • 8% improvement in [smoother/less rough] appearing skin
  • 8% improvement in the appearance of forehead wrinkles
  • Over 7% (7.5%) improvement in the appearance of wrinkles around the eyes
  • Over 7% (7.2%) improvement in more even skin [color/tone]
  • Over 7% (7.1%) improvement in the evenness of skin tone
  • Over 5% (5.8%) improvement in the appearance of cheek wrinkles
  • Over 4% (4.8%) improvement in jaw line contour
  • Over 4% (4.4%) improvement in lift
  • Over 3% (3.6%) improvement in pinch recoil
  • Over 1% (1.1%) improvement in resiliency
• The following percentage of subjects experienced these improvements:^ŧ
  • The skin of 100% of subjects felt [less rough/more smooth]
  • The skin of over 90% (90.3%) of subjects looked more (radiant/ bright)
  • Over 87% (87.1%) of subjects showed decreases in the appearance of facial fine lines
  • The skin of over 77% (77.4%) of subjects was more hydrated
  • The skin of over 77% (77.4%) of subjects looked firmer
  • Pinch recoil was improved in over 77% (77.4%) of subjects
  • The skin of 77% (77.4%) of subjects looked [smoother/less rough]
  • The overall appearance of the skin in over 74% (74.2%) of subjects was improved
  • Photodamage was improved in over 74% (74.2%) of subjects
  • 71% of subjects showed improvements in the appearance of wrinkles around the eyes
  • 71% of subjects showed improvements in the appearance of forehead wrinkles
  • Over 67% (67.7%) of subjects showed improvements in elasticity
  • Over 61% (61.3%) of subjects showed improvements in skin tone
  • The skin of over 58% (58.1%) of subjects was less mottled
  • Over 58% (58.1%) of subjects showed improvements in skin resiliency
  • Over 58% (58.1%) of subjects showed improvements in skin firmness
  • Over 48% (48.4%) of subjects showed improvements in the appearance of wrinkles on their cheeks
  • The jaw line contour was improved in over 48% (48.4%) of subjects
  • Lift was improved in over 45% (45.2%) of subjects
  • Facial spots were decreased in over 38% (38.7%) of subjects
  • The following percentage of subjects reported these positive experiences with the product:*
  • Over 77% (77.4%) said their skin looked radiant and had a youthful glow
  • Over 70% (71%) were satisfied with the results
  • Over 70% (71%) said their skin felt soft and smooth
  • Over 70% (71%) said their skin felt moist and supple
  • Over 67% (67.7%) said their skin had an even tone and texture
  • Over 67% (67.7%) said their skin felt firm
  • Over 64% (64.5%) said the lines around and under their eyes were less noticeable
  • Over 61% (61.3%) said the lines around their lip area were less noticeable
  • Over 64% (64.5%) would recommend the product to their friends and family

^ŧResults and timing vary. It is recommended to use product for eight weeks for optimal results.